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Analytical method of capsizing probability in the time domain for ships in the random beam seas
LIU Liqin, TANG Yougang, LI Hongxia
《结构与土木工程前沿(英文)》 2007年 第1卷 第3期 页码 361-366 doi: 10.1007/s11709-007-0048-5
关键词: different survival probability different significant nonlinear differential narrowband
Multi-stage emergency medicine logistics system optimization based on survival probability
Ke WANG, Yixin LIANG, Lindu ZHAO
《工程管理前沿(英文)》 2017年 第4卷 第2期 页码 221-228 doi: 10.15302/J-FEM-2017020
关键词: emergency medicine logistics ambulance drone survival probability critical illness
Choosing configurations of transmission line tower grounding by back flashover probability value
Dmitry KUKLIN
《能源前沿(英文)》 2016年 第10卷 第2期 页码 213-226 doi: 10.1007/s11708-016-0398-6
关键词: grounding transmission line tower back flashover probability FDTD method
Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma
Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 430-435 doi: 10.1007/s11684-010-0700-7
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 191-203 doi: 10.1007/s11684-016-0450-2
The relationship between telomere length and cancer survival has been widely studied. To gain a deeper insight, we reviewed the published studies. A total of 29 studies evaluated telomere length in the peripheral blood; 22 studies evaluated telomere length in the tumor tissue. First, in the peripheral blood studies, for solid tumor patients with shortened telomere length, the combined hazard ratios (HRs) for mortality and tumor progression were 1.21 (95%CI, 1.10–1.32) and 1.71 (95%CI, 1.37–2.13), respectively. Meanwhile, in hematology malignancy, the combined HRs for mortality and tumor progression were 2.83 (95%CI, 2.14–3.74) and 2.65 (95%CI, 2.18–3.22), respectively. Second, in the studies that use tumor tissue, for patients with shortened telomeres, the combined HRs for mortality and tumor progression were 1.26 (95%CI, 0.95–1.66) and 1.65 (95%CI, 1.26–2.15), respectively. In the studies that calculate the telomere length ratios of tumor tissue to adjacent normal mucosa, for patients with lower telomere length ratios, the combined HRs were 0.66 (95%CI, 0.53–0.83) and 0.74 (95%CI, 0.41–1.32) for mortality and tumor progression, respectively. In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival for cancer patients. However, by calculating the telomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival.
WU Hongchun, LIU Pingping, ZHOU Yongqiang, CAO Liangzhi
《能源前沿(英文)》 2007年 第1卷 第2期 页码 158-166 doi: 10.1007/s11708-007-0020-z
关键词: unstructured geometry assembly transmission probability TPM rectangular
《医学前沿(英文)》 2022年 第16卷 第5期 页码 784-798 doi: 10.1007/s11684-021-0911-0
关键词: uveal melanoma mutant GNAQ/11 palmitoylation BCL2 combination target therapy
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 138-142 doi: 10.1007/s11684-013-0247-5
It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI= 1.12–4.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.
Intracellular trehalose improves the survival of human red blood cells by freeze-drying
HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng
《能源前沿(英文)》 2007年 第1卷 第1期 页码 120-124 doi: 10.1007/s11708-007-0014-x
Evaluating effect of chloride attack and concrete cover on the probability of corrosion
Sanjeev Kumar VERMA, Sudhir Singh BHADAURIA, Saleem AKHTAR
《结构与土木工程前沿(英文)》 2013年 第7卷 第4期 页码 379-390 doi: 10.1007/s11709-013-0223-9
关键词: concrete chloride reinforcement corrosion deterioration cover
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 183-190 doi: 10.1007/s11684-016-0440-4
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms. Eight distinct modules were identified by the WGCNA. Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely correlated with tumor staging. Poor outcomes were found in the low expression group in the turquoise module and in the high expression group in the red module. In addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated pathways were enriched in the turquoise module. Several potential biomarkers, such as cyclin-dependent kinase 1 (CDK1), topoisomerase 2α (TOP2A), and serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1), were also identified. In conclusion, gene signatures identified from the genome-based assays could contribute to HCC stratification. WGCNA was able to identify significant groups of genes associated with cancer prognosis.
关键词: hepatocellular carcinoma coexpression module microarray prognosis
《医学前沿(英文)》 页码 878-888 doi: 10.1007/s11684-023-0993-y
关键词: uveal melanoma liver-directed therapy immune checkpoint blockade SIRT anti-PD-1 anti-CTLA-4
蒋正华
《中国工程科学》 2002年 第4卷 第4期 页码 1-11
从管理学角度回顾了过去百年的世界历史,研究新世纪可能发生的进步,并探讨更好地建立 世界和平与合作,实现共同发展的方案。
孙金华,孙占辉,陆守香,范维澄
《中国工程科学》 2003年 第5卷 第11期 页码 51-55
为了研究不同防灭火安全措施下火灾引起的建筑结构整体坍塌的概率,对典型建筑物的火灾荷载进行了统计分析。利用建筑物火灾的规律及概率与统计理论,给出了典型建筑物的火灾荷载及火灾持续时间的概率分布函数。分析了由火灾引起建筑物坍塌的影响因素,并根据火灾统计结果,得到了写字楼在极端情况下由火灾引起的楼房坍塌概率与其耐火极限时间的关系,导出了一般建筑由于火灾引起的坍塌概率的简单估算方法。
Nonlinear analysis and reliability of metallic truss structures
Karim BENYAHI, Youcef BOUAFIA, Salma BARBOURA, Mohand Said KACHI
《结构与土木工程前沿(英文)》 2018年 第12卷 第4期 页码 577-593 doi: 10.1007/s11709-017-0458-y
关键词: modeling nonlinearity mechanical truss probability reliability response surface probability of failure
标题 作者 时间 类型 操作
Analytical method of capsizing probability in the time domain for ships in the random beam seas
LIU Liqin, TANG Yougang, LI Hongxia
期刊论文
Multi-stage emergency medicine logistics system optimization based on survival probability
Ke WANG, Yixin LIANG, Lindu ZHAO
期刊论文
Choosing configurations of transmission line tower grounding by back flashover probability value
Dmitry KUKLIN
期刊论文
Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma
Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,
期刊论文
Association between telomere length and survival in cancer patients: a meta-analysis and review of literature
null
期刊论文
Transmission probability method based on triangle meshes for solving the unstructured geometry neutron
WU Hongchun, LIU Pingping, ZHOU Yongqiang, CAO Liangzhi
期刊论文
Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal
期刊论文
Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer
null
期刊论文
Intracellular trehalose improves the survival of human red blood cells by freeze-drying
HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng
期刊论文
Evaluating effect of chloride attack and concrete cover on the probability of corrosion
Sanjeev Kumar VERMA, Sudhir Singh BHADAURIA, Saleem AKHTAR
期刊论文
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
期刊论文
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint
期刊论文